Oral GABA supplementation

According to a study published last month in Scientific Reports, participants who consumed a GABA (gamma-aminobutyric acid) dietary supplement demonstrated an increased ability to modulate action control strategies which are needed to quickly and effectively react to fast-moving stimuli (such as driving a car in rush hour).

GABA is a naturally occurring amino acid in the brain and is a major inhibitory neurotransmitter in the central nervous system (CNS). GABA blocks nerve impulses, slowing down the activity of nerve cells and preventing them from over-firing. GABA also serves as a critical calming agent for the body, helping to combat stress and anxiety.

Oral GABA supplementation can act directly on the CNS in a peripheral aspect through the gut. There is definitely a gut-brain relationship between nutrition and the gut microbiome and how they support brain health and function. The gut and brain communicate through the nervous system, immune system, and hormones. In addition, the hypothalamus (emotional neuroendocrine control center of the brain) is outside and not protected by the blood brain barrier, so these two factors can explain how GABA affects the CNS. It is clear in the research that GABA is helpful with anxiety, and there are many case studies which demonstrate its effectiveness.


This new study was the first to investigate if GABA had an effect on planning and controlling different actions.

Thirty participants took 800 mg of GABA or placebo powder mixed with orange juice.

he research team then had them perform a stop-change paradigm, a task that measures how fast people are in inhibiting a response when another action has to be carried out almost simultaneously.

As result, the group that consumed the GABA demonstrated enhanced planning performance. These findings provide the first evidence for a possible causal role of the GABA-ergic system in modulating performance in action cascading.